Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 9/20 | 0.40 |
| ▸ | GSR | P00390 | 4/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GALK1 | P51570 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11304574 | 0.84 | GSR (0.45) | TDP2GSRKDM4CRAF1MAP2K1 | |
| SCHEMBL11307834 | 0.76 | SMN1; SMN2 (0.48) | TDP2GSRKDM4CRAF1MAP2K1 | |
| SCHEMBL6679316 | 0.68 | CBFB (0.44) | TDP2KDM4CRAF1MAP2K1NPC1 | |
| SCHEMBL14301805 | 0.63 | CYP1A2 (0.44) | NPC1LMNAPOLBMAPTRAB9A | |
| SCHEMBL14399199 | 0.61 | SMN1; SMN2 (0.58) | TDP2GSRKDM4CRAF1MAP2K1 | |
| SCHEMBL14958066 | 0.60 | PDE3B (0.35) | LMNAPOLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28566639 | 0.60 | CLK4 (0.42) | LMNAPOLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14957158 | 0.59 | PDE3B (0.34) | LMNAPOLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28411172 | 0.58 | RAB9A (0.37) | NPC1LMNAPOLBMAPTRAB9A | |
| SCHEMBL28603619 | 0.58 | CA2 (0.38) | LMNAPOLBMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030550-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY, Daniel (US) | 1981-06-24 | — | — | EP | claimed |
| WO-1980002799-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY D | 1980-12-24 | — | — | WO | claimed |
| US-4264601-A | SUBSTITUTED ISOALLOXAZINES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 1981-04-28 | — | — | US | disclosed |