Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 9/20 | 0.44 |
| ▸ | TDP2 | O95551 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GALK1 | P51570 | 2/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399199 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL27033894 | 0.78 | KDM4E (0.48) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL11307978 | 0.76 | TDP2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDGSR | |
| SCHEMBL11304574 | 0.76 | GSR (0.45) | SMN1; SMN2KDM4EALDH1A1GSRTDP2 | |
| SCHEMBL16476446 | 0.74 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL19415772 | 0.74 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| Iodide SCHEMBL17254512 | 0.73 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL14212581 | 0.72 | KDM4E (0.48) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL864708 | 0.70 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL14369939 | 0.69 | KDM4E (0.51) | SMN1; SMN2KDM4EALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030550-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY, Daniel (US) | 1981-06-24 | — | — | EP | claimed |
| US-4264601-A | SUBSTITUTED ISOALLOXAZINES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 1981-04-28 | — | — | US | claimed |
| WO-1980002799-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY D | 1980-12-24 | — | — | WO | claimed |
| EP-0030550-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY, Daniel (US) | 1981-06-24 | — | — | EP | disclosed |
| US-4264601-A | SUBSTITUTED ISOALLOXAZINES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 1981-04-28 | — | — | US | disclosed |
| WO-1980002799-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY D | 1980-12-24 | — | — | WO | disclosed |