Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.74 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.74 |
| ▸ | CTSL | P07711 | 1/20 | 0.67 |
| ▸ | CTSS | P25774 | 1/20 | 0.67 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.61 |
| ▸ | MME | P08473 | 1/20 | 0.60 |
| ▸ | ECE1 | P42892 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17279329 | 1.00 | SIRT2 (0.74) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL17694104 | 1.00 | SIRT2 (0.74) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL7689520 | 0.99 | SIRT2 (0.76) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL21357647 | 0.99 | SIRT2 (0.76) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL4787188 | 0.99 | SIRT2 (0.76) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL2963543 | 0.99 | SIRT2 (0.76) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL11332452 | 0.96 | CTSL (0.72) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL4126228 | 0.96 | CTSL (0.72) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| SCHEMBL150166 | 0.96 | CTSL (0.72) | SIRT2SIRT1CTSLCTSSSIRT3 | |
| Hydrochloric Acid SCHEMBL4438043 | 0.95 | CTSL (0.70) | SIRT2SIRT1CTSLCTSSSIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178167-A1 | ASYMMETRIC PIPERAZINE-BASED CATIONIC LIPIDS | TRANSLATE BIO, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| US-9382540-B2 | Compositions and methods for modulating angiopoietin-like 3 expression | ISIS PHARMACEUTICALS, INC (US) | 2016-07-05 | — | — | US | disclosed |
| US-9181550-B2 | Compositions and methods for modulating apolipoprotein (a) expression | ISIS PHARMACEUTICALS, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-9181549-B2 | Conjugated antisense compounds and their use | ISIS PHARMACEUTICALS, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-9145558-B2 | Compositions and methods for modulating HBV expression | ISIS PHARMACEUTICALS, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20150126718-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | US | disclosed |
| EP-0026867-A1 | Peptidylphosphonic acids, their preparation and use, and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-15 | — | — | EP | disclosed |