Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2810754 | 0.84 | CA2 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Propionic Acid SCHEMBL448138 | 0.83 | CES2 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Octanoic Acid SCHEMBL2807929 | 0.80 | CES2 (0.57) | CES1CES2 | |
| Dodecanoate SCHEMBL10935524 | 0.80 | CES2 (0.57) | CES1CES2 | |
| Decanoic Acid SCHEMBL10862164 | 0.80 | CES2 (0.57) | CES1CES2 | |
| Acetic Acid SCHEMBL49139 | 0.79 | CA2 (0.46) | CES1CES2CA2CA4ALPL | |
| Succinic Acid SCHEMBL27632554 | 0.78 | HDAC3 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Acetic Acid SCHEMBL12613566 | 0.77 | CA2 (0.44) | CES1CES2CA2CA4ALPL | |
| Succinic Acid SCHEMBL107086 | 0.76 | HDAC3 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL7944619 | 0.76 | HDAC3 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256804-A | Waterproof coating composition | AUDAX ENTERPRISES, INC. A CORP. OF MD | 1981-03-17 | — | — | US | disclosed |