Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL21957727 | 0.88 | HDAC3 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL4388860 | 0.85 | CA2 (0.46) | CYP1A2CYP2C19TSHRALDH1A1CYP2D6 | |
| Tetraphenylphosphonium SCHEMBL21957717 | 0.84 | ALDH1A1 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL8038474 | 0.84 | CES2 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL1155888 | 0.83 | CA2 (0.44) | CYP1A2CYP2C19TSHRALDH1A1CYP2D6 | |
| Tetraphenylphosphonium SCHEMBL11313501 | 0.83 | HDAC3 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Succinic Acid SCHEMBL6061689 | 0.83 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL11313492 | 0.82 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Tetraphenylphosphonium SCHEMBL1037056 | 0.81 | CA2 (0.42) | CYP1A2CYP2C19TSHRALDH1A1CYP2D6 | |
| Succinic Acid SCHEMBL679440 | 0.79 | CYP2C19 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023194883-A1 | COPOLYMERIZATION OF ORTHO-PHTHALDEHYDE WITH MONOMERS | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2023-10-12 | — | — | WO | disclosed |
| CN-110770274-B | Powder coating compositions containing aromatic polymerizates of aromatic isocyanate production processes | 科思创有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-110770273-B | Powder coating compositions containing aromatic isocyanate-derived polymeric aromatic products | 科思创有限公司 | 2022-02-22 | — | — | CN | disclosed |
| EP-3642255-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | Covestro LLC (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3642254-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | Covestro LLC (US) | 2020-04-29 | — | — | EP | disclosed |
| CN-110770273-A | Powder coating compositions containing aromatic isocyanate-derived polymeric aromatic products | 科思创有限公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-110770274-A | Powder coating compositions containing aromatic polymerizates of aromatic isocyanate production processes | 科思创有限公司 | 2020-02-07 | — | — | CN | disclosed |
| US-10465090-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | COVESTRO LLC (US) | 2019-11-05 | — | — | US | disclosed |
| US-10400112-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | COVESTRO LLC (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180371263-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC | 2018-12-27 | — | — | US | disclosed |
| WO-2018236975-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC (US) | 2018-12-27 | — | — | WO | disclosed |
| WO-2018236972-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC (US) | 2018-12-27 | — | — | WO | disclosed |
| US-20180371287-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC | 2018-12-27 | — | — | US | disclosed |
| WO-2001094463-A1 | POWDER COATING OF EPOXY RESIN, CARBOXYLIC ACID-TERMINATED POLYESTER, STYRENE-MALEIC | SARTOMER TECHNOLOGY COMPANY, INC. (US) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180371287-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | PAH, ALKBH3, AHR | HDAC3 3326/4885HDAC4 2412/4885HDAC1 2611/4885 |
| US-10465090-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | PAH, ALKBH3, AHR | HDAC3 3326/4885HDAC4 2412/4885HDAC1 2611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.