SCHEMBL11318486

SCHEMBL11318486

COc1cc(N)c(C)cc1N=C1C=C(NC(C)=O)C(=O)C=C1C

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10786288 0.92 KDM4E (0.35) KDM4EMAPTHTT
SCHEMBL10787625 0.84 ALDH1A1 (0.36) MAPTHTT
Acetic Acid SCHEMBL11810691 0.83 MAPT (0.36) KDM4EMAPTHTT
SCHEMBL10782015 0.79 KDM4E (0.34) KDM4EMAPTHTT
SCHEMBL11323978 0.78 MAPT (0.35) KDM4EMAPTHTT
SCHEMBL11402669 0.78
SCHEMBL11316324 0.77 TP53 (0.33)
SCHEMBL11783316 0.75 TDP1 (0.31)
SCHEMBL11312129 0.73 ALDH1A1 (0.35) KDM4EMAPTHTT
SCHEMBL11414969 0.73 MAPT (0.36) KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3997348-A FERRIC SALT BLEACHING SOLUTION FUJI PHOTO FILM CO., LTD. (JA) 1976-12-14 US claimed
US-3981676-A HAIR DYES L'OREAL (FR) 1976-09-21 US claimed
US-4246181-A HAIR DYE L'OREAL (FR) 1981-01-20 US disclosed
US-3989447-A Process for nonpermanently dyeing human hair with indamine indoaniline and indophenol hair dyes SOCIETE ANONYME DITE: L'OREAL (FR) 1976-11-02 US disclosed
US-3981678-A HAIR DYES L'OREAL (FR) 1976-09-21 US disclosed
US-3981676-A HAIR DYES L'OREAL (FR) 1976-09-21 US disclosed
US-3960476-A OXIDATION BASE GHILARDI GIULIANA 1976-06-01 US disclosed
US-3953508-A Diphenylamines for dyeing keratinous fibers L'OREAL (FR) 1976-04-27 US disclosed