Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.72 |
| ▸ | CES1 | P23141 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11534869 | 0.96 | CES2 (0.72) | CES2CES1TP53ALDH1A1TSHR | |
| Lithium Ion SCHEMBL29084353 | 0.96 | CES2 (0.72) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL1486898 | 0.96 | CES2 (0.72) | CES2CES1TP53ALDH1A1TSHR | |
| Zinc Ion SCHEMBL8816395 | 0.96 | CES2 (0.72) | CES2CES1TP53ALDH1A1TSHR | |
| Water SCHEMBL9687725 | 0.94 | CES2 (0.70) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL31374765 | 0.84 | CES1 (1.00) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL2156825 | 0.84 | CES1 (1.00) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL181572 | 0.84 | CES2 (0.78) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL8962468 | 0.82 | CES2 (0.75) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL2170995 | 0.82 | CES2 (0.75) | CES2CES1TP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258129-A | IMPROVE GREEN SHELF LIFE | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4211839-A | SILVER HALIDE AND ORGANIC SILVER SALT PREPARED IN AN IMINO COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1980-07-08 | — | — | US | disclosed |
| US-4188212-A | BEZNOTRIAZOLE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-02-12 | — | — | US | disclosed |