⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5633434 | 0.90 | TAAR1 (0.39) | — | |
| SCHEMBL4633672 | 0.80 | PTPN1 (0.40) | — | |
| Biphenyl SCHEMBL9539322 | 0.75 | ALDH1A1 (0.33) | — | |
| SCHEMBL198144 | 0.74 | KCNN4 (0.32) | — | |
| SCHEMBL9463904 | 0.72 | NR1H2 (0.34) | — | |
| SCHEMBL3376281 | 0.72 | TRPA1 (0.35) | — | |
| SCHEMBL29366164 | 0.72 | TRPA1 (0.35) | — | |
| SCHEMBL16975529 | 0.71 | KIF11 (0.37) | — | |
| SCHEMBL9023806 | 0.69 | ALDH1A1 (0.59) | — | |
| SCHEMBL8674236 | 0.69 | FOLH1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590343-A1 | SYNTHESIS OF 2-BUTYL-3-(2 -(1-TRITYL-1H-TETRAZOL-5-YL)BIPHEN YL-4-YL)-1,3-DIAZASPIROL 4,4 -NON-ENE-4-ONE | Teva Pharmaceutical Industries Limited (IL) | 2005-11-02 | — | — | EP | claimed |
| WO-2004072064-A1 | SYNTHESIS OF 2-BUTYL-3-(2'-(1-TRITYL-1H-TETRAZOL-5-YL)BIPHENYL-4-YL)-1,3-DIAZASPIROL[4,4]-NON-ENE-4-ONE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-08-26 | — | — | WO | claimed |
| EP-1919469-B1 | PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST | FARMAPROJECTS S A (ES) | 2011-02-16 | — | — | EP | disclosed |
| EP-2132187-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| US-20080281097-A1 | Process for Preparing an Angiotensin II Receptor Antagonist | FARMAPROJECTS, S. A. (ES) | 2008-11-13 | — | — | US | disclosed |
| WO-2008097459-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-08-14 | — | — | WO | disclosed |
| EP-1749828-A1 | Process for preparing an angiotensin II receptor antagonist | FARMAPROJECTS S.L. (ES) | 2007-02-07 | — | — | EP | disclosed |