SCHEMBL11322012

SCHEMBL11322012

COc1ccc(C(=O)n2ncc3ccccc3c2=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 2/20 0.54
KMT2A Q03164 6/20 0.49
F2 P00734 3/20 0.49
F12 P00748 3/20 0.49
MGAM O43451 1/20 0.49
AMY1A P0DUB6 1/20 0.49
GAA P10253 1/20 0.49
SI P14410 1/20 0.49
MGAM2 Q2M2H8 1/20 0.49
ALDH1A1 P00352 4/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
HPGD P15428 1/20 0.47
PLA2G10 O15496 1/20 0.47
KDM4E B2RXH2 2/20 0.46
UBE2N P61088 1/20 0.46
EGFR P00533 1/20 0.45
TUBB4A P04350 1/20 0.45
TUBB P07437 1/20 0.45
TUBA3C P0DPH7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11311967 0.84 PLA2G10 (0.55) ELANEKMT2AF2MGAMAMY1A
SCHEMBL29462183 0.84 TDP1 (0.44) ELANEKMT2AALDH1A1HPGDPLA2G10
SCHEMBL11318137 0.84 KMT2A (0.52) KMT2AF2F12ALDH1A1HPGD
SCHEMBL4580147 0.75 PLA2G10 (0.50) ELANEKMT2AALDH1A1PLA2G10KDM4E
SCHEMBL4225608 0.74 TDP1 (0.42) ELANEKMT2AALDH1A1CYP1A2CYP2C9
SCHEMBL7365689 0.74 PLA2G10 (0.55) KMT2AALDH1A1PLA2G10KDM4ENPC1
SCHEMBL11310234 0.72 KDM4E (0.46) KMT2AGAAALDH1A1CYP1A2CYP2C9
SCHEMBL7366940 0.72 NPC1 (0.50) KMT2AALDH1A1PLA2G10KDM4ENPC1
SCHEMBL10977450 0.72 PLA2G10 (0.50) KMT2AALDH1A1PLA2G10KDM4ENPC1
SCHEMBL30579886 0.72 TDP1 (0.64) ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4258129-A IMPROVE GREEN SHELF LIFE FUJI PHOTO FILM CO., LTD. (JP) 1981-03-24 US disclosed
US-4211839-A SILVER HALIDE AND ORGANIC SILVER SALT PREPARED IN AN IMINO COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1980-07-08 US disclosed