Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462183 | 0.89 | TDP1 (0.44) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL7365689 | 0.81 | PLA2G10 (0.55) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL10396389 | 0.80 | TFPI2 (0.47) | PKMSMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL11310234 | 0.79 | KDM4E (0.46) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL21431482 | 0.78 | CYP11B2 (0.44) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL31690642 | 0.78 | CYP11B2 (0.44) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL9223856 | 0.77 | NPC1 (0.45) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL11311967 | 0.77 | PLA2G10 (0.55) | NPC1RAB9APKMMITFPLA2G10 | |
| SCHEMBL18396652 | 0.77 | RAB9A (0.49) | NPC1RAB9APKMMITFSMN1; SMN2 | |
| SCHEMBL4580147 | 0.76 | PLA2G10 (0.50) | NPC1RAB9APKMMITFPLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679677-A | CARDIOVASCULAR DISORDERS | LUITPOLD PHARMA GMBH (DE) | 1997-10-21 | — | — | US | disclosed |
| EP-0649839-A1 | Isoquinolinone-, phthalazinone-, quinazolinone- and benzotriazolinone derivatives, their preparation and their use as anti-thrombotics | LUITPOLD PHARMA GmbH (DE) | 1995-04-26 | — | — | EP | disclosed |
| WO-1995009842-A1 | ISOQUINOLINONE-, PHTHALAZINONE-, QUINAZOLINONE- AND BENZOTRIAZOLINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-THROMBOTICS | LUITPOLD PHARMA GMBH (DE) | 1995-04-13 | — | — | WO | disclosed |