Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isonicotinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 10/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 9/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isonicotinic Acid SCHEMBL3705303 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25273196 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL5858849 | 0.95 | CA2 (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25261209 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25273147 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25269382 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25273296 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25270921 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL25271513 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 | |
| Isonicotinic Acid SCHEMBL5216523 | 0.95 | NAPRT (0.56) | NAPRTALDH1A1CA2CA4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4174447-A | SILVER SALTS OF CARBOXY ACIDS | STANDARD OIL COMPANY (INDIANA) (US) | 1979-11-13 | — | — | US | claimed |
| CN-107261148-B | Methylphenidate prodrugs, methods of making and using the same | 凯姆制药公司 | 2021-07-13 | — | — | CN | disclosed |
| EP-3189840-B1 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | KEMPHARM INC (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20190142815-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | ALTER DOMUS (US) LLC | 2019-05-16 | — | — | US | disclosed |
| US-10231960-B2 | Methylphenidate-prodrugs, processes of making and using the same | KEMPHARM INC. (US) | 2019-03-19 | — | — | US | disclosed |
| EP-3189840-A1 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| EP-2736510-B1 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | KEMPHARM INC (US) | 2017-03-01 | — | — | EP | disclosed |
| US-20170049765-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | COMMAVE THERAPEUTICS SA (CH) | 2017-02-23 | — | — | US | disclosed |
| US-9453037-B2 | Methylphenidate-prodrugs, processes of making and using the same | KEMPHARM, INC (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150266911-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | COMMAVE THERAPEUTICS SA (CH) | 2015-09-24 | — | — | US | disclosed |
| US-20140243291-A1 | METHYLPHENIDATE-OXOACID CONJUGATES, PROCESSES OF MAKING AND USING THE SAME | COMMAVE THERAPEUTICS SA (CH) | 2014-08-28 | — | — | US | disclosed |
| EP-2736510-A2 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013016668-A2 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | KEMPHARM INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| US-4258129-A | IMPROVE GREEN SHELF LIFE | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4211839-A | SILVER HALIDE AND ORGANIC SILVER SALT PREPARED IN AN IMINO COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1980-07-08 | — | — | US | disclosed |
| US-4188212-A | BEZNOTRIAZOLE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-02-12 | — | — | US | disclosed |
| US-4188274-A | DECARBOXYLATION | STANDARD OIL COMPANY (INDIANA) (US) | 1980-02-12 | — | — | US | disclosed |
| US-4174447-A | SILVER SALTS OF CARBOXY ACIDS | STANDARD OIL COMPANY (INDIANA) (US) | 1979-11-13 | — | — | US | disclosed |
| US-4012454-A | Iodination process | STANDARD OIL COMPANY (INDIANA) (US) | 1977-03-15 | — | — | US | disclosed |
| US-3970658-A | Nitrile process | STANDARD OIL COMPANY (US) | 1976-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243291-A1 | METHYLPHENIDATE-OXOACID CONJUGATES, PROCESSES OF MAKING AND USING THE SAME | COMT, PNMT, SLC6A3 | NAPRT 836/4885ALDH1A1 97/4885CA2 3529/4885 |
| US-20170049765-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | COMT, TPMT, PNMT | NAPRT 517/4885ALDH1A1 103/4885CA2 3802/4885 |
| US-20150266911-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | COMT, TPMT, PNMT | NAPRT 517/4885ALDH1A1 103/4885CA2 3802/4885 |
| US-20190142815-A1 | Methylphenidate-Prodrugs, Processes of Making and Using the Same | COMT, TPMT, PNMT | NAPRT 517/4885ALDH1A1 103/4885CA2 3802/4885 |
| US-10231960-B2 | Methylphenidate-prodrugs, processes of making and using the same | COMT, TPMT, PNMT | NAPRT 517/4885ALDH1A1 103/4885CA2 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.