Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Isonicotinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 13/20 | 0.56 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.56 |
| ▸ | CA1 known ✓ | P00915 | 12/20 | 0.54 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isonicotinic Acid SCHEMBL7540396 | 0.97 | CA2 (0.54) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25273196 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL11323095 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL3705303 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25271513 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25261209 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25269382 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25270921 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25273147 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 | |
| Isonicotinic Acid SCHEMBL25273296 | 0.95 | NAPRT (0.56) | CA2NAPRTCA4CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132951-A1 | AQUEOUS COMPOSITION WITH A SENNOSIDE AND AT LEAST ONE HYDROTROPE AGENT | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | L'OREAL (FR) | 2025-02-13 | — | — | US | claimed |
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | L'OREAL (FR) | 2024-12-26 | — | — | US | claimed |
| CN-118871078-A | Cosmetic or dermatological composition comprising at least a merocyanine and a hydrotrope | 欧莱雅 | 2024-10-29 | — | — | CN | claimed |
| EP-4447895-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | L'OREAL (FR) | 2024-10-23 | — | — | EP | claimed |
| CN-118804735-A | Cosmetic and/or dermatological composition comprising at least one merocyanine and at least ascorbic acid and/or derivatives thereof | 莱雅公司 | 2024-10-18 | — | — | CN | claimed |
| US-20240322260-A1 | SECONDARY BATTERY AND ELECTRICAL APPARATUS CONTAINING THE SAME | CONTEMPORARY AMPEREX TECHNOLOGY (HONG KONG) LIMITED (CN) | 2024-09-26 | — | — | US | claimed |
| CN-117904657-A | Carbon material supported alloy electrocatalyst and preparation method and application thereof | 西安热工研究院有限公司 | 2024-04-19 | — | — | CN | claimed |
| EP-4318701-A1 | SECONDARY BATTERY AND ELECTRICAL APPARATUS COMPRISING SAME | Contemporary Amperex Technology Co., Limited (CN) | 2024-02-07 | — | — | EP | claimed |
| CN-115536605-B | Preparation method and application of polysubstituted oxazole compound with participation of boron reagent | 广东工业大学 | 2023-12-15 | — | — | CN | claimed |
| US-7008646-B2 | Cubic liquid crystalline compositions and methods for their preparation | CHILDREN'S HOSPITAL RESEARCH FOUNDATION | 2006-03-07 | — | — | US | claimed |
| EP-0897808-B1 | Recording sheets and ink jet printing processes therewith | XEROX CORP (US) | 2004-06-16 | — | — | EP | claimed |
| EP-1361865-A2 | CUBIC LIQUID CRYSTALLINE COMPOSITIONS AND METHODS FOR THEIR PREPARATION | THE PROCTER & GAMBLE COMPANY (US) | 2003-11-19 | — | — | EP | claimed |
| US-20020160040-A1 | Cubic liquid crystalline compositions and methods for their preparation | CHILDREN'S HOSPITAL RESEARCH FOUNDATION | 2002-10-31 | — | — | US | claimed |
| WO-2002066014-A2 | CUBIC LIQUID CRYSTALLINE COMPOSITIONS AND METHODS FOR THEIR PREPARATION | THE PROCTER & GAMBLE COMPANY (US) | 2002-08-29 | — | — | WO | claimed |
| US-6117527-A | RECORDING SHEET COMPRISING SUBSTRATE HAVING IMAGE-RECEIVING COATING ON SURFACE COMPRISING BINDER POLYMER AND SELECTED ADDITIVE; HIGH QUALITY IMAGES WITH REDUCED OR NO HAZE | XEROX CORPORATION (US) | 2000-09-12 | — | — | US | claimed |
| EP-0897808-A1 | Recording sheets and ink jet printing processes therewith | Xerox Corporation (US) | 1999-02-24 | — | — | EP | claimed |
| EP-0272903-B1 | PROCESS FOR PRODUCING A POLYARYLENE SULFIDE | Tosoh Corporation (JP) | 1993-07-21 | — | — | EP | claimed |
| US-4794163-A | HIGH MOLECULAR WEIGHT, HEAT RESISTANCE | TOSOH CORPORATION (JP) | 1988-12-27 | — | — | US | claimed |
| EP-0272903-A2 | Process for producing a polyarylene sulfide | Tosoh Corporation (JP) | 1988-06-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | KRT18, PROC, DSC1 | CA2 797/4885CA4 655/4885CA1 1327/4885 |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | NAPRT, NAMPT, NNMT | CA2 393/4885CA4 843/4885CA1 440/4885 |
| US-20020160040-A1 | Cubic liquid crystalline compositions and methods for their preparation | SKP1, CCNB1, CRYAA | CA2 364/4885CA4 254/4885CA1 54/4885 |
| US-20240322260-A1 | SECONDARY BATTERY AND ELECTRICAL APPARATUS CONTAINING THE SAME | SOD1, SOD3, CAT | CA2 94/4885CA4 724/4885CA1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.