Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11323779 | 0.86 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11324803 | 0.85 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL10425817 | 0.79 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11310998 | 0.77 | OPRM1 (0.36) | SMN1; SMN2MAPTLMNAALDH1A1NPC1 | |
| SCHEMBL11326434 | 0.77 | ACHE (0.39) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11103663 | 0.75 | GLS (0.41) | SMN1; SMN2LMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL11314873 | 0.75 | MAPT (0.35) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11315853 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11100615 | 0.72 | MAPT (0.37) | SMN1; SMN2MAPTALOX12LMNAALDH1A1 | |
| SCHEMBL11377452 | 0.72 | CYP3A4 (0.55) | SMN1; SMN2MAPTLMNAACHEQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307101-A | ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| US-4293697-A | ANTIHISTAMINES | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4230865-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-28 | — | — | US | disclosed |
| US-4226874-A | ANTIHISTAMINES, ANTISECRETORY AGENTS, GASTRIC JUICE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-07 | — | — | US | disclosed |
| US-4151288-A | ANTHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137234-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4018931-A | INHIBITION OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-04-19 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |