Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MYC | P01106 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000440 | 0.79 | ALDH1A1 (0.71) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL392840 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL7495328 | 0.78 | CYP1A2 (0.58) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL31620984 | 0.77 | TSHR (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL653748 | 0.77 | TSHR (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL8248300 | 0.77 | ALDH1A1 (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL30411921 | 0.77 | TSHR (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL653746 | 0.77 | TSHR (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL10902309 | 0.77 | TSHR (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL111279 | 0.77 | TSHR (1.00) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4249022-A | Process for the manufacture of 1,4-disubstituted bicyclic or tricyclic compounds and new 1,4-disubstituted bicyclic compounds | CIBA-GEIGY CORPORATION (US) | 1981-02-03 | — | — | US | disclosed |
| US-4245007-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |
| US-4154754-A | 1,4-Dicyanonaphthalenes | CIBA-GEIGY CORPORATION (US) | 1979-05-15 | — | — | US | disclosed |
| US-4048212-A | Process for the manufacture of 1,4-dicyanonaphthalenes | CIBA-GEIGY CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4011261-A | PROCESS FOR THE MANUFACTURE OF 1,4-DISUBSTITUTED BICYCLIC OR TRICYCLIC COMPOUNDS AND NEW 1,4-DISUBSTITUTED BICYCLIC COMPOUNDS | CIBA-GEIGY CORPORATION (US) | 1977-03-08 | — | — | US | disclosed |