Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | QPCT | Q16769 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11311333 | 0.84 | CA1 (0.38) | LMNAKDM4EALDH1A1GAA | |
| SCHEMBL11310375 | 0.83 | HRH2 (0.35) | HRH2HRH4HRH3LMNAKDM4E | |
| SCHEMBL11323782 | 0.81 | HRH2 (0.36) | HRH2HRH4HRH3LMNAKDM4E | |
| SCHEMBL11356887 | 0.79 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| SCHEMBL11325609 | 0.76 | HRH2 (0.35) | HRH2HRH4HRH3LMNAKDM4E | |
| SCHEMBL11320928 | 0.76 | CA12 (0.36) | LMNAKDM4EALDH1A1TDP1 | |
| SCHEMBL11365036 | 0.75 | LMNA (0.41) | HRH2HRH4LMNAKDM4EQPCT | |
| SCHEMBL11325484 | 0.71 | ALDH1A1 (0.32) | ALDH1A1MAPT | |
| SCHEMBL11324045 | 0.70 | MTNR1B (0.39) | HRH2HRH4HRH3LMNAKDM4E | |
| SCHEMBL11322084 | 0.70 | TERT (0.45) | HRH2HRH4HRH3LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307101-A | ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| US-4293697-A | ANTIHISTAMINES | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4230865-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-28 | — | — | US | disclosed |
| US-4226874-A | ANTIHISTAMINES, ANTISECRETORY AGENTS, GASTRIC JUICE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-07 | — | — | US | disclosed |
| US-4151288-A | ANTHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137234-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4018931-A | INHIBITION OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-04-19 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |