SCHEMBL11325604

SCHEMBL11325604

N#Cc1ccc([P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.N#Cc1ccc([P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O=S(=O)([O-])OOS(=O)(=O)[O-]

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
MAOB P27338 3/20 0.41
MAOA P21397 2/20 0.41
MAPT P10636 1/20 0.41
EEF2K O00418 1/20 0.38
LSS P48449 1/20 0.38
CYP19A1 P11511 3/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA9 Q16790 2/20 0.38
CA12 O43570 1/20 0.38
AR P10275 1/20 0.37
CTSG P08311 1/20 0.36
CMA1 P23946 1/20 0.36
NR3C1 P04150 1/20 0.36
PGR P06401 1/20 0.36
ACLY P53396 1/20 0.36
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11325583 0.90 TSHR (0.41) TSHRMAOBMAOAMAPTEEF2K
Tetraphenylphosphonium SCHEMBL11324663 0.84 HTR6 (0.33) TSHRCA1CA2CA9CA12
SCHEMBL29404656 0.82 TSHR (0.59) TSHRMAOBMAOAMAPTCYP19A1
Bromide SCHEMBL7883475 0.80 TSHR (0.56) TSHRMAOBMAOAMAPTCA2
Hydrochloric Acid SCHEMBL7247582 0.80 TSHR (0.56) TSHRMAOBMAOAMAPTCYP19A1
Tetraphenylphosphonium SCHEMBL6507702 0.73 HTR6 (0.33) TSHRCA1CA2CA9CA12
Tetraphenylphosphonium SCHEMBL1824629 0.72 TSHR (0.42) TSHRMAOBMAOAMAPTEEF2K
Tetraphenylphosphonium SCHEMBL3821606 0.72 HTR6 (0.39) TSHRMAOAMAPTCA1CA2
Benzonitrile SCHEMBL6899298 0.72 TSHR (0.56) TSHRMAOBMAOAMAPTEEF2K
Benzonitrile SCHEMBL4710240 0.70 TSHR (0.67) TSHRMAOBMAOAMAPTEEF2K

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4247620-A TETRAARYL PHOSPHONIUM, AMMONIUM OR ARSONIUM METAL POLYCARBOXYLATES KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-01-27 US disclosed