Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11336373 | 0.82 | PNMT (0.70) | PNMTHTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL11327857 | 0.82 | PNMT (0.70) | PNMTHTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL29750085 | 0.78 | KIF11 (0.42) | PNMTHTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL21525908 | 0.78 | KIF11 (0.42) | PNMTHTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL19684566 | 0.78 | PNMT (0.50) | PNMTHTR2C | |
| SCHEMBL24428893 | 0.78 | CES1 (0.39) | HTR2C | |
| SCHEMBL599446 | 0.78 | CES1 (0.43) | KIF11 | |
| Hydrochloric Acid SCHEMBL5795490 | 0.76 | PNMT (0.49) | PNMTHTR2C | |
| SCHEMBL15502922 | 0.75 | HTR2C (0.50) | PNMTHTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL19674927 | 0.74 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |