SCHEMBL21525908

SCHEMBL21525908

Cc1ccc2c(c1C)CNC2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.42
HTR2C P28335 5/20 0.40
HTR2A P28223 4/20 0.34
HTR2B P41595 4/20 0.34
CD274 Q9NZQ7 1/20 0.31
CYP1A2 P05177 1/20 0.31
ADRA2A P08913 1/20 0.31
PNMT P11086 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
CD44 P16070 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29750085 1.00 KIF11 (0.42) KIF11HTR2CHTR2AHTR2BCD274
SCHEMBL20835027 0.79 TRPA1 (0.31) HTR2B
SCHEMBL21500484 0.78 HTR2C (0.38) KIF11HTR2CHTR2AHTR2BPNMT
SCHEMBL19406884 0.78 HTR2C (0.38) KIF11HTR2CHTR2AHTR2BCYP1A2
SCHEMBL31336038 0.78 HTR2C (0.38) KIF11HTR2CHTR2AHTR2BPNMT
SCHEMBL11325808 0.78 PNMT (0.54) KIF11HTR2CADRA2APNMTADRA2B
SCHEMBL23771285 0.75 HTR2C (0.43) HTR2CHTR2B
SCHEMBL11198207 0.75 HTR2C (0.38) KIF11HTR2CCYP1A2POLB
SCHEMBL29750070 0.73 CD44 (0.42) KIF11HTR2CCYP1A2PNMTCD44
SCHEMBL5068782 0.73 CD44 (0.42) KIF11HTR2CCYP1A2PNMTCD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230097358-A1 INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2023-03-30 US disclosed
CN-114920911-A Method for producing polyisothianaphthene-based conductive polymer 昭和电工株式会社 2022-08-19 CN disclosed
CN-110121516-B Method for producing polyisothianaphthene-based conductive polymer 昭和电工株式会社 2022-07-01 CN disclosed
US-11183340-B2 Method for manufacturing solid electrolytic capacitor SHOWA DENKO K.K. (JP) 2021-11-23 US disclosed
US-11136432-B2 Method for producing polyisothianaphthene-based electroconductive polymer SHOWA DENKO K.K. (JP) 2021-10-05 US disclosed
CN-110121757-B Method for manufacturing solid electrolytic capacitor 昭和电工株式会社 2021-09-14 CN disclosed
US-20200090874-A1 METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR SHOWA DENKO K.K. (JP) 2020-03-19 US disclosed
US-20190345287-A1 METHOD FOR PRODUCING POLYISOTHIANAPHTHENE-BASED ELECTROCONDUCTIVE POLYMER SHOWA DENKO K.K. (JP) 2019-11-14 US disclosed
EP-3564290-A1 METHOD FOR PRODUCING POLYISOTHIANAPHTHENE ELECTROCONDUCTIVE POLYMER Showa Denko K.K. (JP) 2019-11-06 EP disclosed
EP-3564976-A1 METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR Showa Denko K.K. (JP) 2019-11-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230097358-A1 INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE LRRK2, CRBN, MDM2 KIF11 2235/4885HTR2C 1116/4885HTR2A 1642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.