Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11326677 | 1.00 | OPRM1 (0.38) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11326676 | 1.00 | OPRM1 (0.38) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11321409 | 0.81 | HTR2A (0.39) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11321408 | 0.81 | HTR2A (0.39) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11321405 | 0.81 | HTR2A (0.39) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11360995 | 0.78 | ADRA2A (0.37) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11318529 | 0.75 | OPRM1 (0.38) | OPRM1OPRK1OPRL1OPRD1HRH1 | |
| SCHEMBL11845382 | 0.70 | OPRL1 (0.38) | OPRM1OPRK1OPRL1OPRD1KMT2A | |
| SCHEMBL11856554 | 0.68 | OPRL1 (0.49) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL467357 | 0.67 | OPRL1 (0.58) | OPRM1OPRK1OPRL1OPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | claimed |
| US-4301292-A | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1981-11-17 | — | — | US | disclosed |
| US-4292245-A | 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4292243-A | 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | disclosed |
| EP-0027522-A1 | Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-04-29 | — | — | EP | disclosed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | disclosed |