SCHEMBL1132983

SCHEMBL1132983

CC1=CC(=O)N(Cc2ccccc2CN2C(=O)C=C(C)C2=O)C1=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.50
PTGS2 P35354 1/20 0.50
RGS4 P49798 2/20 0.44
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.39
RECQL P46063 1/20 0.39
RPS6KA2 Q15349 1/20 0.39
TGM2 P21980 1/20 0.38
MAPK1 P28482 1/20 0.38
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
CYP2C19 P33261 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
USP2 O75604 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MGLL Q99685 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29676946 1.00 PTGS1 (0.50) PTGS1PTGS2RGS4GAAKDM4E
SCHEMBL28785152 0.91 PTGS1 (0.64) PTGS1PTGS2RGS4GAAKMT2A
SCHEMBL1133694 0.89 PTGS1 (0.43) PTGS1PTGS2RGS4GAAKDM4E
SCHEMBL1133476 0.83 PTGS1 (0.46) PTGS1PTGS2RGS4GAAKDM4E
SCHEMBL907301 0.83 RGS4 (0.64) RGS4KMT2AMEN1MAPTMGLL
SCHEMBL3684400 0.81 PTGS1 (0.40) PTGS1PTGS2RGS4GAAKDM4E
SCHEMBL1133156 0.80 MGLL (0.50) PTGS1PTGS2RGS4MGLL
SCHEMBL7936999 0.78 PTGS1 (0.43) PTGS1PTGS2RGS4GAAKDM4E
SCHEMBL168682 0.78 RGS4 (0.49) RGS4KDM4EMAPK1KMT2AMEN1
SCHEMBL27815835 0.78 PTGS1 (0.47) PTGS1PTGS2GAAKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109303441-B Mattress with adjustable hardness 浙江想能睡眠科技股份有限公司 2021-12-14 CN claimed
US-11064813-B2 Softness-adjustable mattress ZHEJIANG XIANGNENG SLEEP TECHNOLOGY STOCK CO., LTD. (CN) 2021-07-20 US claimed
CN-109043958-B Air bag and mattress 浙江想能睡眠科技股份有限公司 2021-01-12 CN claimed
CN-109157057-B Inflatable product and mattress 浙江想能睡眠科技股份有限公司 2021-01-08 CN claimed
EP-3646759-B1 A SOFTNESS-ADJUSTABLE MATTRESS ZHEJIANG XIANGNENG SLEEP TECH STOCK CO LTD (CN) 2020-12-30 EP claimed
EP-3646759-A1 A SOFTNESS-ADJUSTABLE MATTRESS Zhejiang Xiangneng Sleep Technology Stock Co., Ltd (CN) 2020-05-06 EP claimed
US-20200128968-A1 SOFTNESS-ADJUSTABLE MATTRESS ZHEJIANG XIANGNENG SLEEP TECHNOLOGY STOCK CO., LTD. (CN) 2020-04-30 US claimed
CN-110240735-A A kind of environmentally protective all-steel load-bearing radial tire upper bead filler feed composition and its mixing method 黄果树轮胎有限公司 2019-09-17 CN claimed
EP-2287015-A2 Pneumatic tire Bridgestone Corporation (JP) 2011-02-23 EP claimed
US-20060272760-A1 Pneumatic tire BRIDGESTONE CORPORATION 2006-12-07 US claimed
EP-1297974-A1 PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2003-04-02 EP claimed
US-20030015272-A1 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-23 US claimed
US-11987705-B2 Rubber composition and a tire comprising a rubber composition THE GOODYEAR TIRE & RUBBER COMPANY (US) 2024-05-21 US disclosed
US-20230383100-A1 RUBBER COMPOSITION AND A TIRE COMPRISING A RUBBER COMPOSITION THE GOODYEAR TIRE & RUBBER COMPANY 2023-11-30 US disclosed
EP-4282913-A1 RUBBER COMPOSITION AND A TIRE COMPRISING A RUBBER COMPOSITION The Goodyear Tire & Rubber Company (US) 2023-11-29 EP disclosed
CN-116355292-A High-heat-conductivity low-heat-generation rubber, preparation method thereof and tire 海安橡胶集团股份公司 2023-06-30 CN disclosed
EP-1197518-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE MADE WITH THE SAME BRIDGESTONE CORPORATION (JP) 2002-04-17 EP disclosed
US-6174989-B1 SYNTHETIC RUBBERS AND VULCANIZATION FOR TIRES THE GOODYEAR TIRE & RUBBER COMPANY 2001-01-16 US disclosed
US-5981662-A VULCANIZATES FOR USE IN SIDEWALL, TREAD, CARCASS PLY, WIRECOAT OR OVERLAY COMPOUNDS FOR TIRES; IMPART ANTI-REVERSION AND ANTIFATIGUE PROPERTIES IN THE RUBBER THE GOODYEAR TIRE & RUBBER COMPANY (US) 1999-11-09 US disclosed
EP-0908489-A2 Rubber compounds containing polymeric bis-succinimide polysulfides THE GOODYEAR TIRE & RUBBER COMPANY (US) 1999-04-14 EP disclosed