SCHEMBL168682

SCHEMBL168682

CC1=CC(=O)N(Cc2cccc(CN3C(=O)C=C(C)C3=O)c2)C1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RGS4 P49798 2/20 0.49
CMA1 P23946 2/20 0.44
KMT2A Q03164 5/20 0.43
KDM4E B2RXH2 3/20 0.40
MAPT P10636 3/20 0.40
MAPK1 P28482 3/20 0.40
HPGD P15428 3/20 0.40
MEN1 O00255 3/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
ATM Q13315 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GSK3A P49840 1/20 0.40
GSK3B P49841 1/20 0.40
MGLL Q99685 1/20 0.40
UBE2N P61088 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PABPC1 P11940 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL907301 0.87 RGS4 (0.64) RGS4CMA1KMT2AMAPTHPGD
SCHEMBL21823219 0.87 RGS4 (0.40) RGS4CMA1KMT2AKDM4EMAPT
SCHEMBL1133156 0.85 MGLL (0.50) RGS4CMA1GSK3AGSK3BMGLL
SCHEMBL21738352 0.84 KMT2A (0.41) RGS4KMT2AMAPTMAPK1HPGD
SCHEMBL3677446 0.83 GSK3A (0.43) RGS4KMT2AKDM4EMAPTMEN1
SCHEMBL1133468 0.80 PTGS1 (0.39) RGS4KMT2AMAPTMAPK1HPGD
SCHEMBL1133216 0.80 PTGS1 (0.39) RGS4CMA1KMT2AMAPTMAPK1
SCHEMBL1133694 0.79 PTGS1 (0.43) RGS4KMT2AKDM4EMEN1
SCHEMBL28170505 0.79 RGS4 (0.45) RGS4KMT2AKDM4EMAPTMEN1
SCHEMBL1132983 0.78 PTGS1 (0.50) RGS4KMT2AKDM4EMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 955 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139126-A1 RUBBER COMPOSITIONS AND ARTICLES THEREOF THE GOODYEAR TIRE & RUBBER CO (US) 2026-05-21 US claimed
US-20260139127-A1 RUBBER COMPOSITIONS AND ARTICLES THEREOF THE GOODYEAR TIRE & RUBBER CO (US) 2026-05-21 US claimed
EP-4559967-B1 RUBBER MIXTURES CONTAINING AT LEAST ONE PROCESS AID OF FORMULA (I) LANXESS DEUTSCHLAND GMBH (DE) 2026-05-06 EP claimed
EP-3981612-B1 ARTICLE AND RUBBER COMPOSITION CONTAINING BISMALEIMIDE GOODYEAR TIRE & RUBBER (US) 2025-11-05 EP claimed
EP-4642843-A1 SHEAR BAND HAVING ULTRA-LOW HYSTERESIS RUBBER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2025-11-05 EP claimed
WO-2025108885-A1 RUBBER MIXTURES CONTAINING AT LEAST ONE PROCESSING AID OF FORMULA (I) LANXESS DEUTSCHLAND GMBH (DE) 2025-05-30 WO claimed
EP-4559967-A1 RUBBER MIXTURES CONTAINING AT LEAST ONE PROCESS AID OF FORMULA (I) LANXESS Deutschland GmbH (DE) 2025-05-28 EP claimed
CN-120026533-A Waste rubber asphalt pavement plant-mixing heat regeneration construction process 山西交通科学研究院集团有限公司 2025-05-23 CN claimed
CN-116355292-B High-heat-conductivity low-heat-generation rubber, preparation method thereof and tire 海安橡胶集团股份公司 2025-05-06 CN claimed
WO-2025034218-A1 BETA RADIATION-RESISTANT ELASTOMERIC COMPOSITIONS, ARTICLES, AND METHODS THEREOF BARD PERIPHERAL VASCULAR, INC. (US) 2025-02-13 WO claimed
US-6326438-B1 Rubber containing a bismaleimide and a bisbenzothiazolyldithio end capped compound THE GOODYEAR TIRE & RUBBER COMPANY 2001-12-04 US claimed
US-6079468-A Rubber article containing a bismaleimide and a bis benzothiazolydithio end capped compound THE GOODYEAR TIRE & RUBBER COMPANY (US) 2000-06-27 US claimed
EP-0988999-A2 Antireversion agent for inserts used in runflat tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2000-03-29 EP claimed
US-5985963-A RUBBER, THIOSULFATE AND BISMALEIMIDE THE GOODYEAR TIRE & RUBBER COMPANY (US) 1999-11-16 US claimed
EP-0751178-B1 A sulfur vulcanizable rubber compound GOODYEAR TIRE & RUBBER (US) 1999-09-08 EP claimed
EP-0900820-A1 A rubber compound containing a hydrated thiosulfate and a bismaleimide THE GOODYEAR TIRE & RUBBER COMPANY (US) 1999-03-10 EP claimed
EP-0823453-A1 A rubber compound having improved reversion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1998-02-11 EP claimed
US-5684091-A OF A RUBBER, TETRABENZYLTHIURAM DISULFIDE, A CASHEW NUT OIL MODIFIED NOVOLAK-TYPE PHENOLIC RESIN, A BISMALEIMIDE, A SULFENAMIDE COMPOUND AND SULFUR OR A SULFUR DONOR THE GOODYEAR TIRE & RUBBER COMPANY (US) 1997-11-04 US claimed
US-5623007-A CONTAINING ANTIREVERSION AGENT COMPRISING ZINC SALTS OF CARBOXYLIC ACIDS AND A BIS-CITRACONIMIDO COMPOUND KUMHO TIRE CO., LTD. (KR) 1997-04-22 US claimed
EP-0751178-A1 A sulfur vulcanizable rubber compound THE GOODYEAR TIRE & RUBBER COMPANY (US) 1997-01-02 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260139127-A1 RUBBER COMPOSITIONS AND ARTICLES THEREOF ITCH, BLM, VCL RGS4 1725/4885CMA1 2633/4885KMT2A 1957/4885
US-20260139126-A1 RUBBER COMPOSITIONS AND ARTICLES THEREOF ILK, HUWE1, LRBA RGS4 2181/4885CMA1 2872/4885KMT2A 1728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.