Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11184202 | 0.86 | HTR1A (0.51) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| SCHEMBL11352195 | 0.85 | MAPT (0.52) | ADRB2ADRB1ADRB3CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11185783 | 0.85 | ADRB2 (0.51) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| Hydrochloric Acid SCHEMBL11377640 | 0.84 | MAPT (0.54) | ADRB2ADRB1ADRB3CYP1A2CYP3A4 | |
| SCHEMBL11468630 | 0.82 | ADRB2 (0.63) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| SCHEMBL11449996 | 0.75 | ADRB2 (0.70) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| SCHEMBL13495721 | 0.74 | ADRB2 (0.76) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| SCHEMBL11460105 | 0.73 | ABCB11 (0.51) | HTR1ADRD3ABCB11ADRA2APTGS1 | |
| SCHEMBL11861389 | 0.72 | ADRB1 (0.63) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL11337761 | 0.72 | ADRB2 (0.51) | HTR1AADRA2AADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4215134-A | B-RECEPTOR BLOCKING AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1980-07-29 | — | — | US | claimed |
| EP-0003298-B1 | 4-HYDROXY-2-BENZIMIDAZOLIN-THION DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-03-25 | — | — | EP | disclosed |
| US-4215134-A | B-RECEPTOR BLOCKING AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1980-07-29 | — | — | US | disclosed |