Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15177568 | 0.98 | L3MBTL1 (0.53) | L3MBTL1NPC1RAB9ABCHEACHE | |
| SCHEMBL9044225 | 0.85 | L3MBTL1 (0.61) | L3MBTL1NPC1RAB9AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL11021991 | 0.85 | RAB9A (0.50) | L3MBTL1NPC1RAB9ABCHEACHE | |
| SCHEMBL11020502 | 0.83 | RAB9A (0.51) | L3MBTL1NPC1RAB9ABCHEACHE | |
| Hydrochloric Acid SCHEMBL2356481 | 0.82 | LMNA (0.62) | BCHEACHETDP1TSHR | |
| SCHEMBL13814401 | 0.82 | CYP4F2 (0.50) | BCHEACHETSHR | |
| SCHEMBL6883466 | 0.81 | NPC1 (0.57) | L3MBTL1NPC1RAB9AADRB2ADRB1 | |
| SCHEMBL6057282 | 0.81 | LMNA (0.66) | L3MBTL1NPC1RAB9AADRB2ADRB1 | |
| SCHEMBL29735129 | 0.81 | L3MBTL1 (0.57) | L3MBTL1NPC1RAB9AADRB2ADRB1 | |
| SCHEMBL29735083 | 0.81 | L3MBTL1 (0.57) | L3MBTL1NPC1RAB9AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4271310-A | Method of determining cholinesterase activity and choline derivatives for use in the method | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1981-06-02 | — | — | US | claimed |
| US-4271310-A | Method of determining cholinesterase activity and choline derivatives for use in the method | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1981-06-02 | — | — | US | disclosed |