Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341260 | 0.90 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11457120 | 0.90 | SIGMAR1 (0.42) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11457121 | 0.81 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11454746 | 0.81 | SIGMAR1 (0.51) | SIGMAR1OPRK1 | |
| SCHEMBL11447936 | 0.80 | SIGMAR1 (0.41) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11348029 | 0.79 | OPRM1 (0.49) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11446429 | 0.78 | SIGMAR1 (0.51) | SIGMAR1OPRK1 | |
| SCHEMBL11344639 | 0.78 | SIGMAR1 (0.44) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11338316 | 0.78 | SIGMAR1 (0.44) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11338303 | 0.78 | SIGMAR1 (0.57) | SIGMAR1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |