Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FABP2 | P12104 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28488032 | 0.85 | PTGS1 (0.61) | PTGS1PTGS2ABCC4LTB4RLTB4R2 | |
| SCHEMBL29430898 | 0.85 | PTGS1 (0.61) | PTGS1PTGS2ABCC4LTB4RLTB4R2 | |
| SCHEMBL9420879 | 0.83 | PTGS1 (0.69) | PTGS1PTGS2ABCC4LMNASMN1; SMN2 | |
| SCHEMBL11477693 | 0.83 | PTGS1 (0.58) | PTGS1PTGS2ABCC4LMNASMN1; SMN2 | |
| SCHEMBL11487067 | 0.83 | PTGS1 (0.52) | PTGS1PTGS2ABCC4LTB4RLTB4R2 | |
| SCHEMBL11200592 | 0.80 | PTGS1 (0.44) | PTGS1PTGS2ABCC4LTB4RLTB4R2 | |
| SCHEMBL11200605 | 0.79 | PTGS1 (0.42) | PTGS1PTGS2ABCC4NPC1LMNA | |
| SCHEMBL11339446 | 0.78 | PTGS2 (0.54) | PTGS1PTGS2ABCC4NPC1LMNA | |
| SCHEMBL11474926 | 0.78 | PTGS2 (0.54) | PTGS1PTGS2ABCC4LTB4RLTB4R2 | |
| SCHEMBL9222163 | 0.76 | MAPT (0.59) | PTGS1PTGS2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003893-B1 | NOVEL DIBENZ (B,F) OXEPIN AND DIBENZO (B,F) THIEPIN COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1981-11-04 | — | — | EP | disclosed |