Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11474926 | 0.90 | PTGS2 (0.54) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL11477837 | 0.89 | PTGS2 (0.42) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| Bermoprofen SCHEMBL29454489 | 0.86 | PTGS1 (0.49) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| Bermoprofen SCHEMBL25434 | 0.86 | PTGS1 (0.49) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL11473894 | 0.86 | PTGS2 (0.40) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL14598854 | 0.85 | MAOA (0.44) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL9420879 | 0.85 | PTGS1 (0.69) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL11168809 | 0.84 | HTR1A (0.46) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL11487054 | 0.82 | PTGS1 (0.76) | PTGS2OPRK1PDE4DPTGS1ABCC4 | |
| SCHEMBL11476525 | 0.82 | PTGS2 (0.37) | PTGS2OPRK1PDE4DPTGS1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003893-B1 | NOVEL DIBENZ (B,F) OXEPIN AND DIBENZO (B,F) THIEPIN COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1981-11-04 | — | — | EP | claimed |
| US-4205170-A | ANTIINFLAMMATORY AGENTS | Nippon Chemiphar Company, Limited (JP) | 1980-05-27 | — | — | US | claimed |
| EP-0003893-B1 | NOVEL DIBENZ (B,F) OXEPIN AND DIBENZO (B,F) THIEPIN COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1981-11-04 | — | — | EP | disclosed |
| US-4238620-A | ANTIPYRETICS; ANALGESICS; ANTIINFLAMMATORY AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1980-12-09 | — | — | US | disclosed |
| US-4205170-A | ANTIINFLAMMATORY AGENTS | Nippon Chemiphar Company, Limited (JP) | 1980-05-27 | — | — | US | disclosed |
| EP-0003893-A1 | Novel dibenz (b,f) oxepin and dibenzo (b,f) thiepin compounds and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1979-09-05 | — | — | EP | disclosed |