SCHEMBL11340286

SCHEMBL11340286

CC(Nc1ccccc1)C(=O)NCC#N

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CTSS P25774 8/20 0.50
CTSL P07711 7/20 0.50
CTSK P43235 5/20 0.50
CTSB P07858 5/20 0.50
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11340282 0.86 CTSS (0.41) CTSSCTSLCTSKCTSB
SCHEMBL11338341 0.86 MEN1 (0.54) CTSSCTSLCTSKCTSBALDH1A1
SCHEMBL11332245 0.86 MEN1 (0.49) CTSSCTSLCTSKCTSB
SCHEMBL11336739 0.85 CTSL (0.53) CTSSCTSLCTSKCTSBALDH1A1
SCHEMBL11332768 0.84 ALDH1A1 (0.48) CTSSCTSLCTSKCTSBALDH1A1
SCHEMBL11340032 0.83 CTSS (0.48) CTSSCTSLCTSKCTSBALDH1A1
SCHEMBL11675813 0.83 ALDH1A1 (0.51) ALDH1A1GAA
SCHEMBL6047683 0.81 MME (0.51) ALDH1A1GAA
SCHEMBL11336589 0.80 LMNA (0.50) CTSSCTSLCTSKCTSBGAA
SCHEMBL11332391 0.80 KMT2A (0.52) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4260624-A Fungicidal 2-substituted-3-oxa-3a lambda4,4-dithia-6-chloro-1,5-diazapentalene CHEVRON RESEARCH COMPANY (US) 1981-04-07 US disclosed