Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 6/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11206376 | 0.82 | PSMB8 (0.47) | F2RL3HSP90AA1HSP90AB1KMT2AALDH1A1 | |
| SCHEMBL11347104 | 0.80 | HSD17B10 (0.38) | ELANEKDM4EMAPK1HSD17B10KMT2A | |
| SCHEMBL9843032 | 0.74 | CYP3A4 (0.39) | ELANEKDM4EF2RL3KMT2AALDH1A1 | |
| SCHEMBL6842459 | 0.74 | PTGS1 (0.58) | KDM4EMAPK1F2RL3MEN1KMT2A | |
| SCHEMBL12344033 | 0.74 | TLR8 (0.46) | KDM4EMAPK1F2RL3HSP90AA1HSP90AB1 | |
| SCHEMBL11216904 | 0.73 | ALDH1A1 (0.53) | KDM4EMAPK1HSD17B10F2RL3MEN1 | |
| SCHEMBL7958840 | 0.72 | RAB9A (0.49) | KDM4EHSD17B10ALDH1A1TLR8 | |
| SCHEMBL31063715 | 0.72 | RAB9A (0.49) | KDM4EHSD17B10ALDH1A1TLR8 | |
| SCHEMBL18026590 | 0.70 | ACACB (0.47) | KDM4EHSD17B10KMT2AACACB | |
| SCHEMBL289210 | 0.69 | SMN1; SMN2 (0.56) | MAPK1HSD17B10HSP90AA1HSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039818-A1 | Substituted 2-(3H)-benzothiazolones, processes for their preparation, their utilization in the preparation of medicines and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1981-11-18 | — | — | EP | disclosed |