Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597073 | 0.87 | ALDH1A1 (0.68) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL4596961 | 0.87 | ALDH1A1 (0.68) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL4596965 | 0.87 | ALDH1A1 (0.68) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL1563867 | 0.77 | ALDH1A1 (1.00) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL2304471 | 0.77 | ALDH1A1 (1.00) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL6386661 | 0.76 | ALDH1A1 (0.90) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL3426761 | 0.75 | ALDH1A1 (0.62) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL2932041 | 0.75 | ALDH1A1 (0.62) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL7334247 | 0.75 | ALDH1A1 (0.77) | ALDH1A1PKMKMT2AMEN1GAA | |
| SCHEMBL10536673 | 0.72 | ALDH1A1 (0.68) | ALDH1A1PKMKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285802-B1 | OXO-IMIDAZOLYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY | ASTEX PHARMACEUTICALS INC (US) | 2015-11-11 | — | — | EP | disclosed |
| EP-2285802-B1 | OXO-IMIDAZOLYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY | ASTEX PHARMACEUTICALS INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-8759384-B2 | Oxo-imidazolyl compounds | ASTEXPHRMACEUTICALS, INC. | 2014-06-24 | — | — | US | disclosed |
| US-8759384-B2 | Oxo-imidazolyl compounds | ASTEXPHRMACEUTICALS, INC. | 2014-06-24 | — | — | US | disclosed |
| US-8759384-B2 | Oxo-imidazolyl compounds | ASTEXPHRMACEUTICALS, INC. | 2014-06-24 | — | — | US | disclosed |
| US-20140073639-A1 | INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE | THE ROCKEFELLER UNIVERSITY (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140073639-A1 | INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE | THE ROCKEFELLER UNIVERSITY (US) | 2014-03-13 | — | — | US | disclosed |
| WO-2014026009-A2 | INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE | AVACYN PHARMACEUTICALS, INC. (US) | 2014-02-13 | — | — | WO | disclosed |
| EP-2285802-A1 | OXO-IMIDAZOLYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY | SuperGen, Inc. (US) | 2011-02-23 | — | — | EP | disclosed |
| US-20090298900-A1 | Oxo-Imidazolyl Compounds | ASTEXPHRMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| US-20090298900-A1 | Oxo-Imidazolyl Compounds | ASTEXPHRMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| US-20090298900-A1 | Oxo-Imidazolyl Compounds | ASTEXPHRMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| WO-2009139870-A1 | OXO-IMIDAZOLYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY | SUPERGEN, INC. | 2009-11-19 | — | — | WO | disclosed |
| WO-2009139870-A1 | OXO-IMIDAZOLYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY | SUPERGEN, INC. | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298900-A1 | Oxo-Imidazolyl Compounds | GALE, CYP51A1, GNE | ALDH1A1 965/4885PKM 1469/4885KMT2A 2066/4885 |
| US-20140073639-A1 | INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE | GALE, ENGASE, MGAM | ALDH1A1 4168/4885PKM 3619/4885KMT2A 2869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.