Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342500 | 0.81 | KMT2A (0.43) | HTTKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL11344145 | 0.81 | TDP1 (0.36) | KDM4EALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL14296844 | 0.76 | AURKB (0.45) | ALDH1A1MAPTMAPK1ADORA3RAB9A | |
| SCHEMBL11340563 | 0.73 | LIMK1 (0.47) | ALDH1A1ADORA3HPGDTHRB | |
| SCHEMBL958429 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL11344205 | 0.71 | TP53 (0.41) | KDM4EALDH1A1MAPTADORA3CASP1 | |
| SCHEMBL14786068 | 0.71 | ADORA3 (0.41) | HTTALDH1A1MAPTMAPK1ADORA3 | |
| SCHEMBL11342580 | 0.71 | THRB (0.39) | KDM4EMAPTHPGDTDP1RAB9A | |
| SCHEMBL11334717 | 0.71 | THRB (0.44) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL11345577 | 0.70 | THRB (0.39) | KDM4EMAPTHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4220776-A | TREATMENT OF RHINOVIRAL INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0004319-A1 | N-(pyridothienopyrazol) amides, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-10-03 | — | — | EP | disclosed |