Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342500 | 0.81 | KMT2A (0.43) | KMT2AHPGDKDM4EALDH1A1CASP1 | |
| SCHEMBL11339559 | 0.81 | HTT (0.47) | TDP1ATMTHRBHPGDKDM4E | |
| SCHEMBL11347177 | 0.81 | THRB (0.39) | THRBACACBACACAHPGDKDM4E | |
| SCHEMBL11343058 | 0.79 | KMT2A (0.36) | TDP1KMT2ATHRBACACBACACA | |
| SCHEMBL11345577 | 0.76 | THRB (0.39) | THRBACACBACACAHPGDKDM4E | |
| SCHEMBL11342580 | 0.75 | THRB (0.39) | TDP1KMT2ATHRBACACBACACA | |
| SCHEMBL11340563 | 0.71 | LIMK1 (0.47) | THRBHPGDALDH1A1CLK1IKBKB | |
| SCHEMBL11344205 | 0.69 | TP53 (0.41) | MEN1KMT2ATHRBKDM4EALDH1A1 | |
| SCHEMBL11334717 | 0.69 | THRB (0.44) | KMT2ATHRBHPGDKDM4EALDH1A1 | |
| SCHEMBL11339514 | 0.67 | KDM4E (0.44) | MEN1KMT2AATMTHRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |