Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11333573 | 0.90 | PTGS2 (0.36) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL29481375 | 0.84 | LMNA (0.38) | — | |
| SCHEMBL11339277 | 0.83 | PTGS2 (0.48) | PTGS1PTGS2OPRK1PDE4D | |
| SCHEMBL11332871 | 0.82 | YWHAG (0.36) | — | |
| Bermoprofen SCHEMBL29454489 | 0.80 | PTGS1 (0.49) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Bermoprofen SCHEMBL25434 | 0.80 | PTGS1 (0.49) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL14434968 | 0.80 | PTGS1 (0.41) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL13875314 | 0.79 | PTGS1 (0.38) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Bermoprofen SCHEMBL11441448 | 0.78 | PTGS1 (0.39) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL11473894 | 0.77 | PTGS2 (0.40) | PTGS1ABCC4PTGS2OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003893-B1 | NOVEL DIBENZ (B,F) OXEPIN AND DIBENZO (B,F) THIEPIN COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1981-11-04 | — | — | EP | claimed |
| US-4238620-A | ANTIPYRETICS; ANALGESICS; ANTIINFLAMMATORY AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1980-12-09 | — | — | US | claimed |
| US-4238620-A | ANTIPYRETICS; ANALGESICS; ANTIINFLAMMATORY AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1980-12-09 | — | — | US | disclosed |
| EP-0003893-A1 | Novel dibenz (b,f) oxepin and dibenzo (b,f) thiepin compounds and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1979-09-05 | — | — | EP | disclosed |