Bromide

Bromide

SCHEMBL11344288

Br.C=C(CCCC)c1ccncc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
NAAA Q02083 1/20 0.44
GAA P10253 2/20 0.42
LMNA P02545 3/20 0.40
NPC1 O15118 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
HTT P42858 2/20 0.38
ALDH1A1 P00352 1/20 0.36
CA1 P00915 1/20 0.36
CA9 Q16790 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7560833 0.98 HDAC3 (0.45) HDAC3HDAC1HDAC2NAAAGAA
Bromide SCHEMBL11348026 0.93 NAAA (0.49) HDAC3HDAC1HDAC2NAAAGAA
Bromide SCHEMBL28663673 0.93 NAAA (0.49) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL4629983 0.91 NAAA (0.50) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL4631326 0.91 NAAA (0.50) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL9155329 0.80 NAPRT (0.37) HDAC3HDAC1HDAC2NAAAGAA
Bromide SCHEMBL5436825 0.79 NAPRT (0.39) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL20448 0.78 PTGS2 (0.57) NAAAALDH1A1PTGS2
SCHEMBL7558408 0.77 NAPRT (0.41) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL15964612 0.77 CYP1A2 (0.34) HDAC3HDAC1HDAC2NAAAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4304563-A SHAMPOO OR CONDITIONER TO PREVENT OILY HAIR SOCIETE ANONYNE DITE: L'OREAL (FR) 1981-12-08 US disclosed
US-4177142-A CLUMPING ECODYNE CORPORATION (US) 1979-12-04 US disclosed