Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11334994 | 0.99 | MEN1 (0.45) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11454753 | 0.90 | SIGMAR1 (0.41) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11454730 | 0.89 | MEN1 (0.42) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11348029 | 0.88 | OPRM1 (0.49) | SIGMAR1CHRM3OPRK1OPRM1OPRD1 | |
| SCHEMBL11546721 | 0.83 | ALDH1A1 (0.49) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11550133 | 0.83 | ALDH1A1 (0.49) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11331252 | 0.82 | ALDH1A1 (0.48) | SIGMAR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11454754 | 0.81 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11454732 | 0.81 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11336631 | 0.81 | ALDH1A1 (0.46) | SIGMAR1MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | claimed |
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |