Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL11341625 | 0.94 | KDM4E (0.36) | ALDH1A1KDM4ELMNASMN1; SMN2TDP1 | |
| Glycine SCHEMBL11341473 | 0.92 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNASMN1; SMN2TDP1 | |
| Glycine SCHEMBL11342339 | 0.87 | LMNA (0.41) | ALDH1A1LMNASMN1; SMN2NLRP3HTT | |
| Glycine SCHEMBL11345153 | 0.87 | LMNA (0.37) | ALDH1A1LMNASMN1; SMN2NLRP3HTT | |
| Glycine SCHEMBL11340461 | 0.85 | LMNA (0.41) | ALDH1A1LMNASMN1; SMN2NLRP3HTT | |
| Glycine SCHEMBL11340541 | 0.85 | PTGS2 (0.40) | ALDH1A1KDM4ELMNASMN1; SMN2CHRM1 | |
| Glycine SCHEMBL11351199 | 0.85 | LMNA (0.36) | ALDH1A1LMNANLRP3HTT | |
| Glycine SCHEMBL11350462 | 0.84 | LMNA (0.35) | ALDH1A1LMNASMN1; SMN2NLRP3HTT | |
| Glycine SCHEMBL11347545 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNASMN1; SMN2TDP1 | |
| Glycine SCHEMBL11343414 | 0.81 | LMNA (0.36) | LMNANLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4248886-A | Combating fungi with N-oxalyl-N-phenyl-aminoacids and esters thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-03 | — | — | US | disclosed |