Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL11336203 | 0.94 | CA12 (0.35) | LMNATAS1R3TAS1R1TAS1R2CA12 | |
| Glycine SCHEMBL11347565 | 0.92 | LMNA (0.41) | LMNANLRP3TAS1R3TAS1R1TAS1R2 | |
| Glycine SCHEMBL11342339 | 0.89 | LMNA (0.41) | LMNANLRP3MEN1KMT2ASMN1; SMN2 | |
| Glycine SCHEMBL11340461 | 0.89 | LMNA (0.41) | LMNANLRP3TAS1R3TAS1R1MEN1 | |
| Glycine SCHEMBL11344722 | 0.87 | ALDH1A1 (0.37) | LMNANLRP3SMN1; SMN2HTTALDH1A1 | |
| Glycine SCHEMBL11351199 | 0.87 | LMNA (0.36) | LMNANLRP3HTTALDH1A1 | |
| Glycine SCHEMBL11350462 | 0.86 | LMNA (0.35) | LMNANLRP3SMN1; SMN2HTTALDH1A1 | |
| Glycine SCHEMBL11338366 | 0.84 | PTGS2 (0.42) | NLRP3CA12CA1CA2CA9 | |
| Glycine SCHEMBL11343414 | 0.83 | LMNA (0.36) | LMNANLRP3 | |
| Glycine SCHEMBL11336475 | 0.83 | LMNA (0.36) | LMNANLRP3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4248886-A | Combating fungi with N-oxalyl-N-phenyl-aminoacids and esters thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-03 | — | — | US | disclosed |