Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347502 | 0.98 | CYP3A4 (0.45) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL11303271 | 0.87 | LMNA (0.44) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL11318246 | 0.87 | LMNA (0.44) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL11338730 | 0.82 | CYP3A4 (0.39) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL11344223 | 0.80 | ACHE (0.34) | LMNAACHESMN1; SMN2HTTCYP2C19 | |
| SCHEMBL2964104 | 0.80 | CA12 (0.46) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL3144525 | 0.80 | CA12 (0.46) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL927741 | 0.79 | CYP3A4 (0.47) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL11433852 | 0.79 | LMNA (0.40) | CYP3A4LMNACYP2D6MAPK1THPO | |
| SCHEMBL2962482 | 0.78 | GAA (0.45) | CYP3A4LMNACYP2D6MAPK1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251521-A | HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1981-02-17 | — | — | US | disclosed |