Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10909653 | 0.93 | DHODH (0.45) | TIMP3DHODHAPEX1NPC1RAB9A | |
| SCHEMBL11427857 | 0.87 | CASP6 (0.44) | TIMP3DHODHAPEX1NPC1RAB9A | |
| SCHEMBL11343087 | 0.84 | TIMP3 (0.47) | TIMP3DHODHAPEX1NPC1RAB9A | |
| SCHEMBL11433915 | 0.84 | CASP6 (0.44) | TIMP3DHODHAPEX1NPC1RAB9A | |
| SCHEMBL11426456 | 0.84 | MEN1 (0.55) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11340900 | 0.84 | TIMP3 (0.53) | TIMP3APEX1CA12CA1CA2 | |
| SCHEMBL11588309 | 0.83 | APEX1 (0.65) | TIMP3DHODHAPEX1RAB9AL3MBTL1 | |
| SCHEMBL10823661 | 0.83 | MEN1 (0.43) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL11341877 | 0.83 | P2RY11 (0.46) | TIMP3DHODHAPEX1NPC1RAB9A | |
| SCHEMBL11342265 | 0.83 | TIMP3 (0.48) | TIMP3APEX1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |