Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | PHF13 | Q86YI8 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12513599 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL1135063 | 0.86 | CYP1A2 (0.59) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL12438403 | 0.85 | DRD2 (0.54) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL12438400 | 0.85 | DRD2 (0.54) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL12438394 | 0.85 | DRD2 (0.54) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL1135001 | 0.83 | DRD2 (0.52) | DRD2DRD4DRD3KDM4EATM | |
| SCHEMBL24883473 | 0.82 | KDM4E (0.51) | FOLH1KDM4EATMPOLBGAA | |
| SCHEMBL1135013 | 0.82 | LMNA (0.52) | FOLH1KDM4EATMPOLBGAA | |
| SCHEMBL16725467 | 0.76 | FOLH1 (0.49) | FOLH1KDM4EATMPOLBGAA | |
| SCHEMBL18807575 | 0.73 | FOLH1 (0.71) | FOLH1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178396-A1 | Nicotinamide Derivatives | CRC FOR BIOMEDICAL IMAGING DEVELOPMENT LTD. (AU) | 2011-07-21 | — | — | US | disclosed |
| US-20110178396-A1 | Nicotinamide Derivatives | CRC FOR BIOMEDICAL IMAGING DEVELOPMENT LTD. (AU) | 2011-07-21 | — | — | US | disclosed |
| US-20110178396-A1 | Nicotinamide Derivatives | CRC FOR BIOMEDICAL IMAGING DEVELOPMENT LTD. (AU) | 2011-07-21 | — | — | US | disclosed |
| EP-2285778-A1 | NICOTINAMIDE DERIVATIVES | CRC for Biomedical Imaging Development Ltd (AU) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009129573-A1 | NICOTINAMIDE DERIVATIVES | AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION (AU) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178396-A1 | Nicotinamide Derivatives | NAMPT, NNT, NNMT | DRD2 1612/4885DRD4 1810/4885DRD3 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.