Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135203 | 0.81 | LMNA (0.40) | LMNAKMT2ANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL23219832 | 0.80 | HPGD (0.35) | LMNASMN1; SMN2CYP3A4CYP2C9HPGD | |
| SCHEMBL1135139 | 0.80 | KDM4E (0.37) | LMNAKMT2ANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL1135126 | 0.80 | ALDH1A1 (0.34) | LMNAKMT2ANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL27770834 | 0.78 | SSTR4 (0.42) | LMNACYP4F2CYP4A11KMT2ASMN1; SMN2 | |
| SCHEMBL814188 | 0.76 | KDM4E (0.42) | LMNAKMT2ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL6171233 | 0.74 | KDM4E (0.42) | KDM4EMAPTAOC3ALDH1A1 | |
| SCHEMBL1135148 | 0.72 | CYP4F2 (0.33) | CYP4F2CYP4A11SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29023528 | 0.71 | KDM4E (0.34) | LMNACYP4F2CYP4A11SMN1; SMN2KDM4E | |
| SCHEMBL1291161 | 0.70 | L3MBTL1 (0.43) | LMNAKMT2AKDM4ETSHRABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1958946-B1 | PYRIDAZINE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2011-02-23 | — | — | EP | disclosed |