Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.54 |
| ▸ | CXCL8 | P10145 | 5/20 | 0.50 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.50 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.44 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347865 | 0.86 | CXCL8 (0.55) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL11349860 | 0.86 | PTGS2 (0.52) | PTGS2CXCL8ABCB11PTGS1AKR1B10 | |
| SCHEMBL8956861 | 0.84 | PTGS2 (0.72) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL8956419 | 0.84 | PTGS2 (0.54) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL1032123 | 0.83 | PTGS2 (0.71) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL11346663 | 0.83 | P2RX7 (0.37) | PTGS2CXCL8CLIC1CLCN2P2RX7 | |
| SCHEMBL11353757 | 0.83 | PTGS2 (0.67) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL11373588 | 0.83 | P2RX7 (0.45) | PTGS2CXCL8CLIC1CLCN2TTR | |
| SCHEMBL11343147 | 0.82 | P2RX7 (0.36) | PTGS2CXCL8CLIC1CLCN2P2RX7 | |
| SCHEMBL11342054 | 0.82 | CXCL8 (0.44) | PTGS2CXCL8CLIC1CLCN2TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005559-B1 | PHENYLAMINOTHIOPHENE ACETIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-04 | — | — | EP | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
| EP-0005559-A1 | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-11-28 | — | — | EP | disclosed |