Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.32 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.32 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11346663 | 0.87 | P2RX7 (0.37) | P2RX7NPC1RAB9APTGS2LMNA | |
| SCHEMBL11349016 | 0.83 | P2RX7 (0.33) | P2RX7PTGS2LMNARAPGEF4MEN1 | |
| SCHEMBL11347701 | 0.83 | PTGS2 (0.42) | NPC1RAB9APTGS2JAK2TNF | |
| SCHEMBL11352015 | 0.82 | PTGS2 (0.54) | P2RX7PTGS2CLIC1CXCL8CLCN2 | |
| SCHEMBL11346564 | 0.82 | RAPGEF4 (0.49) | P2RX7PTGS2LMNAALDH1A1MAPT | |
| SCHEMBL11351958 | 0.82 | PTGS2 (0.50) | PTGS2RAPGEF4CLIC1CXCL8CLCN2 | |
| SCHEMBL11350088 | 0.78 | CLCN2 (0.48) | PTGS2LMNAALDH1A1MAPTCLIC1 | |
| SCHEMBL11342075 | 0.78 | CXCL8 (0.45) | NPC1RAB9APTGS2HTTLMNA | |
| SCHEMBL11347652 | 0.74 | PTGS2 (0.43) | PTGS2LMNARAPGEF4CXCL8MEN1 | |
| SCHEMBL11373588 | 0.74 | P2RX7 (0.45) | P2RX7NPC1RAB9APTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005559-B1 | PHENYLAMINOTHIOPHENE ACETIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-04 | — | — | EP | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
| EP-0005559-A1 | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-11-28 | — | — | EP | disclosed |