Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 4/20 | 0.57 |
| ▸ | FGF1 | P05230 | 1/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.52 |
| ▸ | CD40 | P25942 | 1/20 | 0.48 |
| ▸ | CD40LG | P29965 | 1/20 | 0.48 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907420 | 0.93 | CASP6 (0.52) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL11351829 | 0.92 | TIMP3 (0.58) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL11342174 | 0.87 | TIMP3 (0.61) | TIMP3FGF1PRMT1CASP6ENPP2 | |
| SCHEMBL11425433 | 0.87 | CASP6 (0.62) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL11343087 | 0.85 | TIMP3 (0.47) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL10909096 | 0.84 | TIMP3 (0.50) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL10823703 | 0.84 | PRMT1 (0.55) | TIMP3PRMT1CASP6ENPP2CD40 | |
| SCHEMBL11431241 | 0.84 | MAPT (0.55) | CASP6CTDSP1CD40CD40LGAPEX1 | |
| SCHEMBL11350531 | 0.83 | PRMT1 (0.57) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL11340814 | 0.83 | PRMT1 (0.52) | TIMP3FGF1PRMT1CASP6ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |