Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 9/20 | 0.42 |
| ▸ | DDO | Q99489 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13015488 | 0.82 | DAO (0.50) | DAODDOAURKAMAPTADORA3 | |
| SCHEMBL29502192 | 0.82 | DAO (0.50) | DAODDOAURKAMAPTADORA3 | |
| SCHEMBL7330649 | 0.81 | DAO (0.53) | DAODDOGRIA1GRIA2GRIA3 | |
| SCHEMBL10503087 | 0.79 | PSMB8 (0.60) | DAOGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL20571788 | 0.77 | GRIA1 (0.38) | DAOGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1135509 | 0.77 | CYP19A1 (0.45) | DAOGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7319991 | 0.76 | KIF11 (0.38) | GRIA1GRIA2GRIA3GRIA4ADORA3 | |
| SCHEMBL1135870 | 0.72 | DAO (0.45) | DAODDOAURKAGRIA1GRIA2 | |
| SCHEMBL1135841 | 0.71 | DAO (0.50) | DAOMAPTADORA2AKDM4EALDH1A1 | |
| SCHEMBL29580191 | 0.71 | PSMB8 (0.55) | DAOGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285786-B1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | claimed |
| US-8329698-B2 | Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-12-11 | — | — | US | claimed |
| JP-2011524384-A | — | — | 2011-09-01 | — | — | JP | claimed |
| US-20110130404-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-06-02 | — | — | US | claimed |
| EP-2285786-A1 | QUINOXALINEDIONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-02-23 | — | — | EP | claimed |
| WO-2009152909-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-23 | — | — | WO | claimed |
| US-8674097-B2 | Quinoxalinedione derivatives useful as activators of AMPK-activated protein kinase | MERCK PATENT GMBH (DE) | 2014-03-18 | — | — | US | disclosed |
| EP-2285786-B1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20120322806-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-20 | — | — | US | disclosed |
| US-8329698-B2 | Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20110130404-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-06-02 | — | — | US | disclosed |
| EP-2285786-A1 | QUINOXALINEDIONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009152909-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130404-A1 | QUINOXALINEDIONE DERIVATIVES | GLP1R, GPR119, NDUFS3 | DAO 2101/4885DDO 1438/4885AURKA 3251/4885 |
| US-20120322806-A1 | QUINOXALINEDIONE DERIVATIVES | GLP1R, GPR119, NDUFS3 | DAO 2101/4885DDO 1438/4885AURKA 3251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.