SCHEMBL11366155

SCHEMBL11366155

Cc1ccc(N(C)[C@H](C(=O)O)C(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TSHR P16473 2/20 0.40
MMP2 P08253 2/20 0.40
MMP9 P14780 2/20 0.40
MMP13 P45452 2/20 0.40
MMP8 P22894 1/20 0.40
ADAMTS4 O75173 1/20 0.40
SRD5A2 P31213 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
RAB9A P51151 1/20 0.37
MMP1 P03956 1/20 0.36
MMP3 P08254 1/20 0.36
MMP7 P09237 1/20 0.36
ALOX5 P09917 1/20 0.36
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3340746 0.85 ADAMTS4 (0.49) ALDH1A1SMN1; SMN2TSHRMMP2MMP9
SCHEMBL3340749 0.85 ADAMTS4 (0.49) ALDH1A1SMN1; SMN2TSHRMMP2MMP9
SCHEMBL11201192 0.84 ALDH1A1 (0.41) ALDH1A1TSHRMMP2MMP9MMP13
SCHEMBL31467998 0.84 ALOX5 (0.42) ALDH1A1SMN1; SMN2TSHRSRD5A2SLC6A2
SCHEMBL14969086 0.82 ADAMTS4 (0.59) ALDH1A1SMN1; SMN2MMP2MMP9MMP13
SCHEMBL31370844 0.81 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2TSHRSLC6A2SLC6A4
SCHEMBL8605929 0.81 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2TSHRSLC6A2SLC6A4
SCHEMBL9241878 0.80 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2TSHRMMP2MMP9
SCHEMBL14843771 0.80 CHRM5 (0.42) ALDH1A1SMN1; SMN2MMP2MMP9MMP13
SCHEMBL29173925 0.78 CYP2D6 (0.48) ALDH1A1SMN1; SMN2SLC6A2SLC6A4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4243819-A Substituted amino acids ZOECON CORPORATION (US) 1981-01-06 US disclosed