Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRE | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28420959 | 0.90 | TDP1 (0.53) | TDP1CAMK2AGABRPGABRDGABRA1 | |
| Succinic Acid SCHEMBL29364481 | 0.89 | TDP1 (0.59) | TDP1CAMK2AGABRPGABRDGABRA1 | |
| Succinic Acid SCHEMBL1134610 | 0.89 | TDP1 (0.59) | TDP1CAMK2AGABRPGABRDGABRA1 | |
| Isobutanol SCHEMBL7067169 | 0.86 | TSHR (0.50) | CAMK2AGABRPGABRDGABRA1GABRB1 | |
| Adipic Acid SCHEMBL902718 | 0.85 | GPR84 (0.54) | TDP1CAMK2ALMNAGPR84FFAR1 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2032943 | 0.85 | SLC22A6 (0.42) | CAMK2AGABRPGABRDGABRA1GABRB1 | |
| Lactic Acid SCHEMBL21356987 | 0.84 | TP53 (0.58) | CAMK2AGABRPGABRDGABRA1GABRB1 | |
| Adipic Acid SCHEMBL10936251 | 0.84 | LMNA (0.58) | TDP1LMNAGPR84FFAR1FFAR4 | |
| Adipic Acid SCHEMBL346488 | 0.84 | LMNA (0.58) | TDP1LMNAGPR84FFAR1FFAR4 | |
| Glutarate SCHEMBL28304978 | 0.84 | SLC22A6 (0.58) | TDP1CAMK2ALMNAGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112955560-A | Method for optimizing gas utilization | 朗泽科技有限公司 | 2021-06-11 | — | — | CN | disclosed |
| US-4293686-A | CONTAINING A HYDROXY HALD ESTER, MALEIC ANHYDRIDE AND AN UNSATURATED MONOMER | UNION CARBIDE CORPORATION (US) | 1981-10-06 | — | — | US | disclosed |