Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | BRD2 | P25440 | 2/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519416 | 0.90 | PDE4A (0.56) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL9055277 | 0.81 | PDE4A (0.61) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL7154209 | 0.80 | ADORA2B (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL11497052 | 0.77 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL836619 | 0.77 | MEN1 (0.77) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL1713301 | 0.76 | MEN1 (0.71) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL9010501 | 0.75 | ADORA2B (0.62) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL11458744 | 0.74 | MEN1 (0.74) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL11367602 | 0.73 | PDE4A (0.42) | MEN1KMT2AALDH1A1PDE4AADORA2A | |
| SCHEMBL11460096 | 0.72 | MEN1 (0.65) | MEN1KMT2AALDH1A1PDE4AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023032-A1 | Process for the preparation of oxoalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-01-28 | — | — | EP | claimed |
| US-4289776-A | VASODILATORS, FIBRINOLYTIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0023032-A1 | Process for the preparation of oxoalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-01-28 | — | — | EP | disclosed |