Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GPR65 | Q8IYL9 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11360427 | 0.94 | CHRM2 (0.35) | CHRM2CHRM1CHRM3PREPJAK1 | |
| SCHEMBL11355893 | 0.86 | GPR65 (0.35) | GPR65 | |
| SCHEMBL11356592 | 0.81 | ALDH1A1 (0.32) | CHRM1JAK3 | |
| SCHEMBL11475130 | 0.81 | RIPK1 (0.32) | GPR65 | |
| Fumaric Acid SCHEMBL11354325 | 0.77 | TSHR (0.32) | — | |
| SCHEMBL11360365 | 0.76 | CHRM2 (0.32) | CHRM2CHRM1CHRM3PREPJAK1 | |
| SCHEMBL11360366 | 0.74 | KMT2A (0.37) | GPR65 | |
| SCHEMBL31692322 | 0.74 | CHRM2 (0.43) | CHRM2CHRM1CHRM3PREPJAK1 | |
| SCHEMBL31692475 | 0.74 | CHRM2 (0.43) | CHRM2CHRM1CHRM3PREPJAK1 | |
| SCHEMBL11352706 | 0.72 | PTGS1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277472-A | 3,6-Disubstituted-5,7-(lower alkano)-5,6,7,8-tetrahydropyrido(4,3-C)pyridazines; their intermediates, preparation, antihypertensive use and compositions | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-07-07 | — | — | US | disclosed |