Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22270825 | 0.85 | HSP90AA1 (0.59) | HSP90AA1L3MBTL1NPC1LIMK1LMNA | |
| SCHEMBL11373216 | 0.78 | RXFP1 (0.46) | HSP90AA1L3MBTL1NPC1LIMK1LMNA | |
| SCHEMBL30454452 | 0.76 | HSP90AA1 (0.50) | HSP90AA1L3MBTL1NPC1LIMK1LMNA | |
| SCHEMBL21297755 | 0.75 | HSP90AA1 (0.73) | HSP90AA1L3MBTL1NPC1LMNACCR1 | |
| SCHEMBL11367413 | 0.75 | CDC7 (0.48) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL22270667 | 0.74 | ADORA2A (0.43) | HSP90AA1L3MBTL1NPC1LIMK1LMNA | |
| SCHEMBL12070710 | 0.74 | KDM4E (0.48) | LMNANOS3NOS1NOS2DHFR | |
| SCHEMBL11368804 | 0.73 | L3MBTL1 (0.40) | HSP90AA1L3MBTL1NPC1LIMK1LMNA | |
| SCHEMBL12733673 | 0.72 | DCPS (0.52) | NPC1LMNADHFRPRMT5HTT | |
| SCHEMBL30287027 | 0.72 | HSP90AA1 (0.50) | HSP90AA1L3MBTL1NPC1LIMK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686199-B9 | FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR | CSTONE PHARMACEUTICALS SUZHOU CO LTD (CN) | 2022-12-07 | — | — | EP | disclosed |
| US-11312715-B2 | Fused ring derivative as A2A receptor inhibitor | CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. (CN) | 2022-04-26 | — | — | US | disclosed |
| US-20200239465-A1 | FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR | CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2020-07-30 | — | — | US | disclosed |
| EP-3686199-A1 | FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR | CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. (CN) | 2020-07-29 | — | — | EP | disclosed |
| US-4260759-A | CONDENSATION OF NITRILES | SCHERING-CORPORATION (US) | 1981-04-07 | — | — | US | disclosed |
| US-4115395-A | FUNGICIDES, BACTERICIDES | SCHERING CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |
| US-4107166-A | ANTIFUNGAL, ANTIBACTERIAL | SCHERING CORPORATION (US) | 1978-08-15 | — | — | US | disclosed |
| US-4017500-A | FUNGICIDES, BACTERICIDES | SCHERING CORPORATION (US) | 1977-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312715-B2 | Fused ring derivative as A2A receptor inhibitor | ADORA2A, ADORA2B, ADORA1 | HSP90AA1 3780/4885L3MBTL1 4009/4885NPC1 695/4885 |
| US-20200239465-A1 | FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR | ADORA2A, ADORA2B, ADORA1 | HSP90AA1 3780/4885L3MBTL1 4009/4885NPC1 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.