Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28162801 | 0.82 | HSD17B10 (0.50) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL23860776 | 0.78 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8404531 | 0.78 | GPR3 (0.56) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL509768 | 0.77 | LMNA (0.37) | KDM4EHSD17B10ALDH1A1ADRA2AADORA2A | |
| SCHEMBL8489704 | 0.75 | CYP2A6 (0.39) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| Hydrochloric Acid SCHEMBL508815 | 0.75 | LMNA (0.36) | KDM4EALDH1A1ADRA2AHTTDHFR | |
| SCHEMBL509508 | 0.75 | CYP3A4 (0.43) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11365189 | 0.75 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11374086 | 0.75 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11370489 | 0.74 | HSP90AA1 (0.53) | KDM4EALDH1A1HTTDHFRNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126843-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2023-02-08 | — | — | EP | disclosed |
| EP-2935291-B1 | IRIDIUM COMPLEXES USED IN OLIGOMERS, POLYMERS OR DENDRIMERS IN ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | disclosed |
| CN-109096178-A | Phenylethynyl substituted benzenes and heterocycles useful for the treatment of cancer and uses thereof | 肯塔基大学研究基金会 | 2018-12-28 | — | — | CN | disclosed |
| US-20170309832-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170309832-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-9673402-B2 | Platinum metal complexes with divalent groups bridging two ligands | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9673402-B2 | Platinum metal complexes with divalent groups bridging two ligands | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20150349277-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| EP-2726490-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014094960-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| WO-2013000531-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-01-03 | — | — | WO | disclosed |
| WO-2011157339-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-12-22 | — | — | WO | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| WO-2010086089-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150349277-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | KDM4E 3816/4885HSD17B10 2888/4885ALDH1A1 3721/4885 |
| US-20110284799-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | KDM4E 3816/4885HSD17B10 2888/4885ALDH1A1 3721/4885 |
| US-20130082209-A1 | METAL COMPLEXES | MCOLN2, MCOLN1, AP1M1 | KDM4E 4129/4885HSD17B10 3651/4885ALDH1A1 2790/4885 |
| US-20170309832-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | KDM4E 3816/4885HSD17B10 2888/4885ALDH1A1 3721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.